Publications


  1. Wan ES, Li Y, Lao, T, Qiu W, Jiang Z, Mancini JD, Owen CA, Clish C, DeMeo DL, Silverman EK, Zhou X. Metabolomic profiling in a Hedgehog Interacting Protein (Hhip) murine model of chronic obstructive pulmonary disease. Scientific Report, Accepted, 2017.

  2. Qiu W*, Guo F*, Glass K, Yuan GC, Quakenbush J, Zhou X, Tantisira K. Differential Connectivity of Gene Regulatory Networks Distinguishes Corticosteroid Response in Asthma. J of Allergy and Clinical Immunology, 2017 Accepted. (*, Co-first author).

  3. Morrow J.D, Zhou X, Lao T, Jiang Z, DeMeo D, Cho MH, Qiu W, Cloonan S,  Pinto-Plata V, Celli B, Marchetti N, Criner G et al. Functional interactors of three genome-wide association study genes are differentially expressed in severe chronic obstructive pulmonary disease lung tissue. Scientific Report, 2017 Mar 13;7:44232.

  4. Yun JH, Morrow J, Owen CA, Qiu W, Glass K, Lao T, Jiang Z, Perrella MA, Silverman EK, Zhou X, Hersh CP. Transcriptomic Analysis of Lung Tissue from Cigarette Smoke Induced Emphysema Murine Models and Human COPD Show Shared and Distinct Pathways. Am J Respir Cell Mol Biol. 2017 Mar 1.

  5. Jiang Z, Knudsen N, Wang G, Qiu W, Naing Z, Bai Y, Ai X, Lee C, Zhou X; Genetic control of fatty acid β-oxidation in chronic obstructive pulmonary disease. 2017, Am J Respir Cell Mol Biol.

  6. Lao T, Jiang Z, Yun J, Qiu W, Guo F, Huang C, Mancini JD, Gupta K, Laucho-Contreras ME, Naing ZZ, Zhang L, Perrella MA, Owen CA, Silverman EK, Zhou X. Hhip haploinsufficiency sensitizes mice to age-related emphysema. Proc Natl Acad Sci U S A. 2016 Aug 9;113(32):E4681-7

  7. McGeachie MJ, Yates KP, Zhou X, Guo F, Sternberg AL, Van Natta ML, Wise RA, Szefler SJ, Sharma S, Kho AT, Cho MH, Croteau-Chonka DC, Castaldi PJ, Jain G, Sanyal A, Zhan Y, Lajoie BR, Dekker J, Stamatoyannopoulos J, Covar RA, Zeiger RS, Adkinson NF, Williams PV, Kelly HW, Grasemann H, Vonk JM, Koppelman GH, Postma DS, Raby BA, Houston I, Lu Q, Fuhlbrigge AL, Tantisira KG, Silverman EK, Tonascia J, Strunk RC, Weiss ST. CAMP Research Group. Genetics and Genomics of Longitudinal Lung Function Patterns in Asthmatics. Am J Respir Crit Care Med. 2016 Jul 1

  8. Girodet PO, Nguyen D, Mancini JD, Hundal M, Zhou X, Israel E, Cernadas M. Alternative Macrophage Activation is Increased in Asthma. Am J Respir Cell Mol Biol. 2016 Jun 1

  9. Jiang Z, Polverino F, Lao T, Qiu W, Gupta K, Mancini J.D, Cho MH, Castaldi PJ, Guo F, Sun Y, Yu J, Laucho-Contreras ME, Kobzik L, Raby BA, Choi AMK, Perrella MA, Owen CA., Silverman EK and Zhou X. FAM13A, A Chronic Obstructive Pulmonary Disease Susceptibility Gene, Negatively Regulates the β-catenin/Wnt Pathway. 2016, Feb 10, Am J Respir Crit Care Med (In Press)

  10. Hobbs BD, Parker MM, Chen H, Lao T, Hardin M, Qiao D, Hawrylkiewicz I, Sliwinski P, Yim JJ, Kim WJ, Kim DK, Castaldi PJ, Hersh CP, Morrow J, Celli BR, Pinto-Plata VM, Criner GJ, Marchetti N, Bueno R, Agusti A, Make BJ, Crapo JD, Calverley PM, Donner CF, Lomas DA, Wouters EF, Vestbo J, Paré PD, Levy RD, Rennard SI, Zhou X, Laird NM, Lin X, Beaty TH, Silverman EK, Cho MH; NETT Genetics, ECLIPSE, COPDGene and International COPD Genetics Network Investigators. Exome Array Analysis Identifies A Common Variant in IL27 Associated with Chronic Obstructive Pulmonary Disease. 2016 Jan 15, Am J Respir Crit Care Med (In press)

  11. McGeachie MJ*, Yates KP*, Zhou X, Guo F, Sternberg AL, Van Natta M, Wise RA, Szefler S, Sharma S, Kho AT, Cho MH, Croteau-Chonka DC, Castaldi PJ, Jain G, Sanyal A, Zhan Y, Lajoie BR, Dekker J, Stamatoyannopoulos J, Covar RA, Zeiger RS, Adkinson NF, Williams PV, Kelly HW, Grasemann H, Vonk JM, Koppelman G, Postma D, Raby B, Houston I, Lu Q, Fuhlbrigge A, Tantisira K, Silverman EK, Tonascia J, Weiss ST, Strunk RC. Patterns of Lung Function Growth and Decline in Persistent Childhood Asthma. N Engl J Med 2016; In Press. (*, Co-first author)

  12. Lao T, Glass K, Qiu W, Gupta K, Morrow J, Mancini JD, Vuong L, Perrella MA, Hersh CP, Owen CA, Quackenbush J, Yuan G, Silverman EK , and Zhou X*. Haploinsufficiency of Hedgehog interacting protein causes increased emphysema induced by cigarette smoke through network rewiring. Genome Medicine, 2014

  13. Sharma A, Menche J, Huang C, Ort T, Zhou X, Kitsak M, Sahni N, Thibault D, Voung L, Guo F, Gulbahce N, Baribaud F, Tocker J, Dobrin R, Barnathan E, Liu H, Panettieri RA Jr, Tantisira KG, Qiu W, Raby BA, Silverman EK, Vidal M, Weiss ST, Barabasi AL. A disease module in the interactome explains disease heterogeneity, drug response and captures novel pathways and genes. Hum Mol Genet. 2015

  14. Castaldi PJ, Cho MH, Zhou X, Qiu W, Mcgeachie M, Celli B, Bakke P, Gulsvik A, Lomas DA, Crapo JD, Beaty TH, Rennard S, Harshfield B, Lange C, Singh D, Tal-Singer R, Riley JH, Quackenbush J, Raby BA, Carey VJ, Silverman EK, Hersh CP. Genetic control of gene expression at novel and established chronic obstructive pulmonary disease loci. Hum Mol Genet. 2015 Feb 15;24(4):1200-10.

  15. Sharma S*, Zhou X*, Thibault DT, Himes BE, Liu A, Szefler SJ, Strunk R, Castro M, Hansel N, Diette GB, Vonakis BM, Adkinson NF, Avila L, Soto-Quiros M, Barraza-Villareal A, Lemanske RF, Solway J, Krishnan J, White SR, Cheadle C, Berger AE, Fan J, Boorgula MP, Nicolae D, Gilliland F, Barnes K,. London SJ, Martinez F, OberC, Celedon J, Carey VJ, Weiss ST, Raby RA. A genome-wide survey of CD4+ lymphocyte regulatory genetic variants identifies novel asthma genes. J of Allergy and Clinical Immunology, 2014.

  16. Cho M, McDonald M., Zhou X, Mattheisen M, Castaldi P, Hersh C, DeMeo D, Sylvia J, Ziniti J, Laird N, Lange C, Litonjua A, Sparrow D, Casaburi R, Barr R, Regan E, MD, Make B, Hokanson J, Lutz S, Dudenkov T, Farzadegan H, Hetmanski J, Tal-Singer R, Lomas D, Bakke P, Gulsvik A, Crapo J, Silverman EK, Beaty TH. A Genome-Wide Association Identifies Risk Loci for Severe Chronic Obstructive Pulmonary Disease. Lancet Respiratory Medicine, 2014, March; 2(3):214-25.

  17. Zhou X#, Qiu W, Sathirapongsasuti JF, Cho MH, Mancini JD, Lao T, Thibault DM, Litonjua G, Bakke PS, Gulsvik A, Lomas DA, Beaty TH, Hersh CP, Anderson C, Geigenmuller U, Raby BA, Rennard SI, Perrella MA, Choi AMK, Quackenbush J, Silverman EK#. Gene expression analysis uncovers novel hedgehog interacting protein (HHIP) effects in human bronchial epithelial cells. Genomics, 2013, March. (#corresponding author)

  18. Li CG, Zhou X, Sun Y, Zhang E, Mancini JD, Parkhitko A, Morrison TA, Silverman EK, Henske EP, Yu J. Faslodex inhibits estradiol-induced ECM dynamics and lung metastasis in a model of LAM. Am J of Cell and Mol Bio, 2013.

  19. Zhou X#, Baron RM, Hardin M, Cho MH, Zielinski J, Hawrylkiewicz I, Sliwinski,P, Hersh CP, Mancini JD, Lu K, Thibault D, Donahue AL, Klanderman BJ, Rosner B, Raby BA, Lu Q, Geldart AM, Layne MD, Perrella MA, Weiss ST, Choi AMK, Silverman EK#. Identification of a chronic obstructive pulmonary disease genetic determinant that regulates HHIP. Human Molecular Genetics, 2012, Mar 15;21(6):1325-35.(#corresponding author)

  20. Lange N.E, Zhou X, Lasky-Su J, Himes B.E., Lazarus R, Soto-Quiros M, Avila L, Celedon J C, Hawrylowicz C M, Raby BA and Litonjua A. Comprehensive genetic assessment of a functional TLR9 promoter polymorphism: no replicable association with asthma or asthma-related phenotypes. BMC Medical Genetics, 2011, Feb 15, 12:26.

  21. Zhou X#, Munger K. Clld7, A Candidate Tumor Suppressor on Chromosome 13q14, Regulates Pathways of DNA Damage/Repair and Apoptosis. Cancer Research, 2010, 70(22): 9434-9443. (#: corresponding author)

  22. Yang S, He S, Zhou X, Liu M, Zhu H, Wang Y, Zhang W, Yan S, Quan L, Bai J, Xu N. Suppression of Aurora-A Oncogenic Potential by c-Myc Down regulation. Exp Mol Med. 2010 Oct 1.

  23. Zhou X, Munger K. Expression of the Human Papillomavirus type 16 E7 oncoprotein induces an autophagy-related process and sensitizes normal human keratinocytes to cell death in response to growth factor deprivation. Virology. 2009;385(1):192-197.

  24. Zhou X, Spangle JM, Munger K. Expression of a viral oncoprotein in normal human epithelial cells triggers an autophagy-related process: Is autophagy an "Achilles' heel" of human cancers? Autophagy. 2009;5(4): 578-579.

  25. Wang Y, Liu S, Zhu H, Zhang W, Zhang G, Zhou X, Zhou C, Quan L, Bai J, Xue L, Lu N, Xu N. FRAT1 overexpression leads to aberrant activation of beta-catenin/TCF pathway in esophageal squamous cell carcinoma. Int J Cancer. 2008 Aug 1;123(3):561-8.

  26. Huh K, Zhou X, Hayakawa H, Cho JY, Libermann TA, Jin J, Harper JW, Munger K. The Human Papillomavirus type 16 E7 oncoprotein associates with the cullin 2 ubiquitin ligase complex, which contributes to degradation of the retinoblastoma tumor suppressor. J of Virology. 2007;81(18):9737-47.

  27. Yang SB*, Zhou X*, Zhu HX, Quan LP, Bai JF, He J, Gao YN, Cheng SJ, Xu NZ. Amplification and Overexpression of Aurora-A in Esophageal Squamous Cell Carcinoma. Oncol Report. 2007;17(5):1083-8. (*Co-first author).

  28. Wang Y, Hewitt SM, Liu S, Zhou X, Zhu H, Zhou C, Zhang G, Quan L, Bai J, Xu N. Tissue microarray analysis of human FRAT1 expression and its correlation with the subcellular localization of beta-catenin in ovarian tumor. Br J Cancer. 2006;94(5):686-91.

  29. Zhang G*, Zhou X*, Xue L, Quan L, Wang Y, Zhou C, Lu N, Wang Q, Zhu H, Xu N. (*Co-first author). Accumulation of cytoplasmic beta-catenin correlates with reduced expression of E-cadherin, but not with phosphorylated Akt in esophageal squamous cell carcinoma: an immunohistochemical study. Pathology International. 2005;55(6):310-317.

  30. Wang Y*, Zhou X*, Zhu H, Liu S, Zhou C, Zhang G, Xue L, Lu N, Quan L, Bai J, Zhan Q, Xu N. (*Co-first author). Overexpression of EB1 in human esophageal squamous cell carcinoma (ESCC): promoting cellular growth by the activating beta-catenin/TCF pathway. Oncogene. 2005;24(44):6637-6645.

  31. Zhou C, Liu S, Zhou X, Xue L, Quan L, Lu N, Zhang G, Bai J, Wang Y, Liu Z, Zhan Q, Zhu H, Xu N. Overexpression of human pituitary tumor transforming gene (hPTTG), is regulated by beta-catenin/TCF pathway in human esophageal squamous cell carcinoma. International Journal of Cancer. 2005;113(6):891-898.

  32. Wang YH, Liu S, Zhang G, Zhou CQ, Zhu HX, Zhou X, Quan LP, Bai JF, Xu NZ. Knockdown of c-Myc expression by RNAi inhibits MCF-7 breast tumor cells growth in vitro and in vivo. Breast Cancer Research. 2005;7(2):R220-R228.

  33. Zhou X, Guo M, Quan LP, Zhang W, Lu ZM, Wang QH, Ke Y, Xu NZ. Detection of human papillomavirus in Chinese esophageal squamous cell carcinoma and its adjacent normal epithelium. World J Gastroenterology. 2003;9(6):1170-1173.


© 2017 - The Zhou Lab